Succinylcholine (1 mg/kg, 1.5 mg/kg) without pretreatment or succinylcholine (1 mg/kg, 1.5 mg/kg) with pretreatment by pancuronium (bolus 1 mg, 2 mg), and d-tubocurarine (3 mg, 6 mg bolus) were given to patients of relatively same physlcal status (ASA classification class Ⅰ, Ⅱ) at induction of general anesthesia to determine the degree of muscle fasciculation, vocal cord paralysis, onset and extnt of muscle pain in each group.
The result are summarized as follows
1. Appearance of muscle fasciculation was significantly decreased with pretreatment of non-depolarizing muscle relaxant. (p<0.005)
2. The depressing effect of muscle fasciculation was relatively same in each dosage of non-depolarizing muscle relaxant, thus there is no statistic difference.
3. Degree of vocal cord paralysis was predominant in group of succinylcholine alone used.
Degree of vocal cord paralysis was slightly decreased by pretreatment of non-depolarizing muscle relaxant, but comparision with control group, there is no statistic difference. (p>0.05)
4. The reduced effect of vocal cord paralysis was relatively same in each dosage of non-depolarizing muscle relaxant, thus there is no statistical difference. (p>0.05)
5. Appearance of muscle pain was decreased by pretreatment of non-depolarizing muscle relaxant, especially pretreatment of pancuronium 2 mg bolus significantly decreased post-operative muscle pain.
(When succinyline 1 mg/kg administration : 0.025
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